Search results for: “30”

  • 2023 CPIC Conference Call Minutes

    January Voora slides February Hertz slides Surprenant slides March CPIC update April May El Rouby slides June Saulsberry slides August Pratt slides Newman slides September October Tuteja slides December Caudle slides Phillips slides FDA response to codeine citizen petition

  • CPIC® Guideline for G6PD

    Guideline overview presentation Most recent guideline publication: Expanded Clinical Pharmacogenetics Implementation Consortium (CPIC) Guideline for Medication Use in the Context of G6PD Genotype (August 2022) Tables  provided in the main manuscript of the guideline: Table 1. Assignment of predicted G6PD phenotype based on genotype Table 2. Drug-specific risk level and associated strength of recommendation for…

  • Clinical Pharmacogenetics Implementation Consortium

    ClinPGx 2024: Knowledge, Implementation, Education MeetingJune 20th and 21st, 2024 in Philadelphia, PA More information What is CPIC? The Clinical Pharmacogenetics Implementation Consortium (CPIC®) is an international consortium of individual volunteers and a small dedicated staff who are interested in facilitating use of pharmacogenetic tests for patient care. One barrier to implementation of pharmacogenetic testing in…

  • About Us

    Kelly E. Caudle, PharmD, PhD, BCPS, FCCP CPIC Co-PI/Director, Department of Pharmaceutical Sciences, St. Jude Children’s Research Hospital, Memphis, TN Dr. Caudle received her Pharm.D. and Ph.D. from The University of Tennessee Health Science Center and completed an ASHP-accredited PGY2 residency at Le Bonheur Children’s Hospital in Memphis, TN. She is also a board‐certified Pharmacotherapy…

  • CPIC® Guideline for Atomoxetine based on CYP2D6 genotype

    Most recent guideline publication: Clinical Pharmacogenetics Implementation Consortium (CPIC) Guideline for CYP2D6 Genotype and Atomoxetine (February 2019) Updates since publication: October 2019: CYP2D6 genotype to phenotype translation changes: Up until August 2019, there were a few inconsistencies in the translation of CYP2D6 genotype to phenotype across guidelines (i.e. CPIC and DPWG) and between clinical genetic…

  • CPIC® Guideline for Potent Volatile Anesthetic Agents and Succinylcholine and RYR1 and CACNA1S

    Most recent guideline publication: Clinical Pharmacogenetics Implementation Consortium (CPIC) guideline for the use of potent volatile anesthetic agents and succinylcholine in the context of RYR1 or CACNA1S genotypes Updates since publication: December 2023: Subsequent to the publication of the CPIC guideline for RYR1 and malignant hyperthermia (PMID 30499100), the ClinGen variant curation expert panel (VCEP) developed and published…

  • Meetings

    ClinPGx 2024 Meeting Registration open In collaboration with CPIC, PharmGKB, PharmCAT and PharmVar, the Penn Institute for Biomedical Informatics will be hosting the ClinPGx 2024: Knowledge, Implementation, Education meeting on June 20th and 21st, 2024 in Philadelphia, PA. This meeting will provide educational content to cover all aspects of PGx implementation. Participants are invited to submit…

  • CPIC® Guideline for Tacrolimus and CYP3A5

    Most recent guideline publication: Clinical Pharmacogenetics Implementation Consortium (CPIC) Guidelines for CYP3A5 genotype and Tacrolimus Dosing (July 2015) Updates since publication: No updates on dosing recommendations since publication. Tables provided in the main manuscript of the guideline: Table 1. Assignment of likely metabolism phenotypes based on CYP3A5 diplotypes Table 2. Dosing recommendations for tacrolimus based…

  • CPIC® Guideline for Ivacaftor and CFTR

    Most recent guideline publication: Clinical Pharmacogenetics Implementation Consortium (CPIC) Guidelines for Ivacaftor Therapy in the Context of CFTR Genotype (March 2014) Updates since publication: May 2019: The FDA-approved drug label for ivacaftor has been updated to include additional variants, bringing the total number of indicated variants to 38. The CPIC guideline supplement and CFTR Allele…

  • CPIC® Guideline for Fluoropyrimidines and DPYD

    Most recent guideline publication: Clinical Pharmacogenetics Implementation Consortium (CPIC) Guideline for Dihydropyrimidine Dehydrogenase Genotype and Fluoropyrimidine Dosing: 2017 Update (October 2017) Updates since publication: January 2024 update: Recently, individual patients have been reported (PMID 38129972) to carry only one of the two SNPs in the HapB3 haplotype (i.e., c.1236G>A without c.1129-5923C>G), suggesting that the two…