Search results for: “fto”

Most recent guideline publication: Clinical Pharmacogenetics Implementation Consortium (CPIC) Guidelines for Ivacaftor Therapy in the Context of CFTR Genotype (March 2014) Updates since publication: May 2019: The FDA-approved drug label for ivacaftor has been updated to include additional variants, bringing the total number of indicated variants to 38. The CPIC guideline supplement and CFTR Allele…

CPIC guideline for ivacaftor based on CFTR genotype   For gene-specific information tables (i.e. CFTR allele definition and gene resource mappings tables) see guideline page or PharmGKB.

Prioritizing the order of writing guidelines for CPIC genes/drugs is based on the following criteria: CPIC guidelines published, in progress, or planned Gene – Drug Current CPIC level* Status TPMT, NUDT15 – thiopurines A Published; update in progress CYP2C19 – clopidogrel A Published CYP2C9,VKORC1, CYP4F2 – warfarin A Published CYP2D6 – opioids A Published HLA-B…