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Kelly E. Caudle, PharmD, PhD, BCPS, FCCP CPIC Co-PI/Director, Department of Pharmaceutical Sciences, St. Jude Children’s Research Hospital, Memphis, TN Dr. Caudle received her Pharm.D. and Ph.D. from The University of Tennessee Health Science Center and completed an ASHP-accredited PGY2 residency at Le Bonheur Children’s Hospital in Memphis, TN. She is also a board‐certified Pharmacotherapy…

Licensing and terms of use for CPIC content CPIC resources are freely available for use by anyone. All curated content published by CPIC is available free of restriction under the CC0 1.0 Universal (CC0 1.0) Public Domain Dedication. However, CPIC requests that you give attribution to CPIC whenever possible and appropriate and that you acknowledge:…

CPIC’s therapeutic recommendations are based on weighing the evidence from a combination of preclinical functional and clinical data, as well as on some existing disease-specific consensus guidelines. Some of the factors that are taken into account in evaluating the evidence supporting therapeutic recommendations include: in vivo pharmacokinetic and pharmacodynamic data, in vitro enzyme activity of…

Most recent guideline publication: Clinical Pharmacogenetics Implementation Consortium (CPIC) Guidelines for Human Leukocyte Antigen-B (HLA-B) Genotype and Allopurinol Dosing (February 2013) Updates since publication: June 2015 update: Guideline authors reviewed additional literature and concluded that none of the evidence would change the therapeutic recommendations in the 2013 guideline; therefore, the 2013 guideline remains clinically current.…

Overview Presentation These slides describes CPIC, the underlying assumptions of CPIC guidelines, the guideline development process and how the guidelines can be implemented in a clinical setting. Overview presentation slides A brief video overview of CPIC can be found here. A one-page summary of CPIC can be found here. A video reviewing CPIC levels and…

Goal and Focus A formal working group within CPIC was formed in 2013 to focus on informatics aspects of CPIC guidelines, especially as they relate to the application of the CPIC guidelines in electronic health records (EHRs) with clinical decision support (CDS). The goal of the CPIC Informatics Working Group is to support the adoption…