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CPIC® Guideline for Rasburicase and G6PD

Most recent guideline publication:

Clinical Pharmacogenetics Implementation Consortium (CPIC) Guidelines for Rasburicase Therapy in the context of G6PD Deficiency Genotype (August 2014)

Updates since publication:

September 2018: The CPIC authors recommend that the G6PD A variant be categorized as IV/normal function (previously II-IV/Deficient-Normal function) based on new evidence supporting function (PMID 27040960 and 30206300). This change has been incorporated into G6PD allele definition table.

Tables and figure provided in the main manuscript of the guideline:

Table 1. Assignment of likely G6PD phenotypes based on genotype/diplotype
Table 2. Recommended therapeutic use of rasburicase in relation to G6PD phenotype
Figure 1. Workflow for interpreting G6PD genotype and for assessing the need for an enzyme activity test.

Supplement to: Clinical Pharmacogenetics Implementation Consortium (CPIC) Guidelines for Rasburicase Therapy in the context of G6PD Deficiency Genotype (August 2014)

Tables included in the supplementa:

Supplemental Table S1. G6PD genetic variants and likely conferred enzyme phenotype For an updated version of this table see the G6PD allele definition table .
Supplemental Table S2. Association between allelic variants and G6PD function as defined by the WHO For an updated version of this table see the G6PD allele definition table .
Supplemental Table S3. World-wide estimates of G6PD deficiency prevalence overall
Supplemental Table S4. Frequencies of G6PD variants available with commercial testing in major race/ethnic groups
Supplemental Table S5. Frequencies of G6PD variants in specific populations
Supplemental Table S6. Drug and compound safety reviews for G6PD deficient patients
Supplemental Table S7. Evidence linking G6PD deficiency to Rasburicase-induced hemolysis or methemoglobinemia

aSome of the tables included in the guideline may have been updated on-line, particularly to reflect newly described or newly characterized alleles. These include the gene-specific information tables (https://www.pharmgkb.org/page/pgxGeneRef) that support CPIC guidelines by providing information regarding star (*) allele definitions, allele function, allele frequency by major ethnic groups, translations of diplotype to phenotype, and gene resource mappings.

Additional resources applicable to this guideline:

Drug resource mapping

Gene resource mapping