Search results for: “12”

Most recent guideline publication: Clinical Pharmacogenetics Implementation Consortium (CPIC) guideline for CYP2D6, OPRM1, and COMT genotype and select opioid therapy (December 2020) Tables and figure provided in the main manuscript of the guideline: Table 1. Assignment of predicted CYP2D6 phenotypes based on diplotypes Table 2. Codeine therapy recommendations based on CYP2D6 phenotype Table 3. Tramadol…

Most recent guideline publication: Clinical Pharmacogenetics Implementation Consortium (CPIC) Guideline for CYP2D6 and CYP2C19 Genotypes and Dosing of Selective Serotonin Reuptake Inhibitors (August 2015) Updates since publication: October 2019: CYP2D6 genotype to phenotype translation changes: Up until August 2019, there were a few inconsistencies in the translation of CYP2D6 genotype to phenotype across guidelines (i.e.…

Most recent guideline publication: Clinical Pharmacogenetics Implementation Consortium (CPIC) Guideline for Dihydropyrimidine Dehydrogenase Genotype and Fluoropyrimidine Dosing: 2017 Update (October 2017) Updates since publication: January 2024 update (edited March 2024): Recently, individual patients have been reported (PMID 38129972) to carry only one of the two SNPs in the HapB3 haplotype (i.e., c.1236G>A without c.1129-5923C>G), suggesting…

Most recent guideline publication: Clinical Pharmacogenetics Implementation Consortium Guidelines for thiopurine dosing based on TPMT and NUDT15 genotypes: 2018 Update (November 2018) Updates since publication: March 2024: At the time of guideline publication, the extent of dosage reduction for thiopurines recommended for patients with intermediate metabolism for both TPMT and NUDT15 was unclear. A recent publication…

Most recent guideline publication: Clinical Pharmacogenetics Implementation Consortium Guideline (CPIC®) for CYP2D6 and CYP2C19 Genotypes and Dosing of Tricyclic Antidepressants: 2016 Update (December 2016) Updates since publication: October 2019: CYP2D6 genotype to phenotype translation changes: Up until August 2019, there were a few inconsistencies in the translation of CYP2D6 genotype to phenotype across guidelines (i.e.…

Most recent guideline publication: Clinical Pharmacogenetics Implementation Consortium Guidelines for HLA-B Genotype and Abacavir Dosing (April 2012) Updates since publication: May 2014 : Guideline authors reviewed additional literature and concluded that none of the evidence would change the therapeutic recommendations in the 2012 guideline; therefore, the 2012 guideline remains clinically current. The guideline supplement and…

Goal and Focus A formal working group within CPIC was formed in 2013 to focus on informatics aspects of CPIC guidelines, especially as they relate to the application of the CPIC guidelines in electronic health records (EHRs) with clinical decision support (CDS). The goal of the CPIC Informatics Working Group is to support the adoption…

Listed below are links to PubMed entries for each paper.   Links to see the guideline page will take you to a webpage where you can download the guideline manuscript, supplement and any other related files.  There, you will also find information about when the guideline was published and the most recent update of the guideline. Citations Guideline…