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What is CPIC?

The Clinical Pharmacogenetics Implementation Consortium (CPIC®) is an international consortium of individual volunteers and a small dedicated staff who are interested in facilitating use of pharmacogenetic tests for patient care.

One barrier to implementation of pharmacogenetic testing in the clinic is the difficulty in translating genetic laboratory test results into actionable prescribing decisions for affected drugs.

CPIC’s goal is to address this barrier to clinical implementation of pharmacogenetic tests by creating, curating, and posting freely available, peer-reviewed, evidence-based, updatable, and detailed gene/drug clinical practice guidelines (click here for all CPIC publications).  CPIC guidelines follow standardized formats, include systematic grading of evidence and clinical recommendations, use standardized terminology, are peer-reviewed, and are published in a leading journal (in partnership with Clinical Pharmacology and Therapeutics) with simultaneous posting to cpicpgx.org, where they are regularly updated.

CPIC started as a shared project between PharmGKB and the Pharmacogenomics Research Network (PGRN) in 2009. CPIC guidelines are available on guidelines.gov, indexed in PubMed as clinical guidelines, endorsed by ASHP and ASCPT, and referenced in ClinGen and PharmGKB.

Team

Leader
Mary V. Relling, Pharm.D.
St. Jude Children’s Research Hospital, Memphis

Leader
Teri E. Klein, Ph.D.
Stanford University

Director
Kelly Caudle, Pharm.D., Ph.D.
St. Jude Children’s Research Hospital, Memphis

Steering Committee

Mary V. Relling, Pharm.D. St. Jude Children’s Research Hospital, Memphis

Teri E. Klein, Ph.D. Stanford University

Julie A. Johnson, Pharm.D. University of Florida

Dan M. Roden, M.D. Vanderbilt University

Rachel F. Tyndale, Ph.D. University of Toronto and CAMH

Scientific Advisory Board

Gwendolyn A. McMillin, Ph.D. ARUP Laboratories

John David Nolan, M.D., Ph.D., Cerner

Robert Nussbaum, M.D. University of California, San Francisco

Heidi Rehm, Ph.D. Partners Healthcare

Marc S. Williams, M.D. Geisinger

Brad Strock, Epic

  • Pharmacogenomics on Nightly News with Lester Holt June 29, 2017
    The Wednesday, June 28th edition of the Nightly News with Lester Holt featured a short segment on pharmacogenomics.The piece briefly covered the Mayo Clinic's work in expanding the use of pharmacogenomics in the clinic. Dr. Richard Weinshilboum, co-director of the pharmacogenomics program at the Mayo Clinic, was also interviewed. Dr. Weinshilboum is a leader in […]
  • CPIC Survey Available Online May 24, 2017
    An important function of CPIC (Clinical Pharmacogenetics Implementation Consortium) is to receive feedback from, and give feedback to, our user communities.  CPIC has posted a survey that is part of that feedback and contains questions regarding priorities for CPIC guidelines, as well as feedback on SNOMED CT term submissions.  CPIC requests completion of the survey by […]
  • Congratulations to Dr. Teri Klein! February 19, 2017
    PharmGKB is pleased to announce that the Stanford Provost has approved Dr. Teri Klein’s appointment as a Professor of Biomedical Data Science! This appointment is effective March 1 and represents a great acknowledgement of Teri’s academic contributions and leadership in data science and pharmacogenomics.  Teri and Russ Altman will remain CoPIs of PharmGKB and continue […]
  • CPIC Guideline Update: CYP2C9/VKORC1/CYP4F2 and Warfarin February 15, 2017
    The 2017 update of CPIC guideline for pharmacogenetics-guided warfarin dosing has been accepted for publication in Clinical Pharmacology and Therapeutics. CPIC extensively reviewed the literature up to Dec 2016. Both the dosing recommendations and supplemental information were updated. The accepted article can currently be viewed on the PharmGKB and CPIC websites.The 2017 update includes the following updates and additions:Updated dosing recommendations […]
  • CPIC Guideline Summary Videos Available on PharmGKB January 27, 2017
    A new resource is available on PharmGKB to help researchers and clinicians more easily and quickly understand CPIC recommendations and how to find supporting information on the PharmGKB website. Short ~5 minute videos describe the role of the gene(s) and the impact of genetic variation on drug response, provide an overview of the genotype-phenotype terminology […]