CPIC guidelines are designed to help clinicians understand HOW available genetic test results should be used to optimize drug therapy, rather than WHETHER tests should be ordered. A key assumption underlying the CPIC guidelines is that clinical high-throughput and pre-emptive (pre-prescription) genotyping will become more widespread, and that clinicians will be faced with having patients’ genotypes available even if they have not explicitly ordered a test with a specific drug in mind.  CPIC’s guidelines, processes and projects have been endorsed by several professional societies – read more.

Each CPIC guideline adheres to a standard format, and includes a standard system for grading levels of evidence linking genotypes to phenotypes, how to assign phenotypes to clinical genotypes, prescribing recommendations based on genotype/phenotype, and a standard system for assigning strength to each prescribing recommendation. The SOP for guideline creation has been published in Current Drug Metabolism: Incorporation of Pharmacogenomics into Routine Clinical Practice: The Pharmacogenetics Implementation Consortium (CPIC) Guideline Development Process. The CPIC authorship guidelines were updated in June 2014.

View CPIC’s process for prioritizing CPIC guidelines