Search results for: “ryr1”

CPIC guideline for potent volatile anesthetic agents and succinylcholine based on RYR1 and CACNA1S genotype   For gene-specific information tables (i.e. RYR1 allele definition and allele functionality tables) see guideline pages or PharmGKB.

Most recent guideline publication: Clinical Pharmacogenetics Implementation Consortium (CPIC) guideline for the use of potent volatile anesthetic agents and succinylcholine in the context of RYR1 or CACNA1S genotypes Updates since publication: December 2023: Subsequent to the publication of the CPIC guideline for RYR1 and malignant hyperthermia (PMID 30499100), the ClinGen variant curation expert panel (VCEP) developed and published…

CPIC guideline for potent volatile anesthetic agents and succinylcholine based on RYR1 and CACNA1S genotype   For gene-specific information tables (i.e. CACNA1S allele definition and allele functionality tables) see guideline pages or PharmGKB.

In 2016, CPIC led a consensus effort to standardize terms for clinical pharmacogenetic tests. The goal of the project was to create standardized terms for pharmacogenetic allele function and phenotypes to be used in CPIC guidelines (specifically Tables 1 and 2) and in the larger pharmacogenetics community (Term Standardization Part 1). However, additional standardization opportunities…

Prioritizing the order of writing guidelines for CPIC genes/drugs is based on the following criteria: CPIC guidelines published, in progress, or planned Gene – Drug Current CPIC level* Status TPMT, NUDT15 – thiopurines A Published; update in progress CYP2C19 – clopidogrel A Published CYP2C9,VKORC1, CYP4F2 – warfarin A Published CYP2D6 – opioids A Published HLA-B…