CPIC® Guideline for Proton Pump Inhibitors and CYP2C19

Most recent guideline publication: Clinical Pharmacogenetics Implementation Consortium (CPIC) Guideline for CYP2C19 and Proton Pump Inhibitor Dosing (August 2020)

Updates since publication:

No updates on dosing recommendations since publication.

Tables provided in the main manuscript of the guideline:

Table 1. Assignment of predicted CYP2C19 phenotype based on genotype

Table 2. Dosing recommendations for omeprazole, lansoprazole, pantoprazole, and dexlansoprazole based on CYP2C19 phenotype

Supplement to: Clinical Pharmacogenetics Implementation Consortium (CPIC) Guideline for CYP2C19 and Proton Pump Inhibitor Dosing
(August 2020)

Tables provided in the guideline publication supplement or referenced in the guideline^a:

Table S1. Evidence linking CYP2C19 to omeprazole phenotype

Table S2. Evidence linking CYP2C19 to lansoprazole phenotype

Table S3. Evidence linking CYP2C19 to pantoprazole phenotype

Table S4. Evidence linking CYP2C19 to dexlansoprazole phenotype

Table S5. Evidence linking CYP2C19 to esomeprazole phenotype

Table S6. Evidence linking CYP2C19 to rabeprazole phenotype

Table S7. Evidence linking CYP2C19 to proton pump inhibitor phenotype (mixed cohort)

Table S8. Dosing recommendations for esomeprazole and rabeprazole based on CYP2C19 phenotype

CYP2C19 allele definition table

CYP2C19 allele functionality table

CYP2C19 frequency table

CYP2C19 diplotype-phenotype table

Gene resource mapping CYP2C19 gene resource mappings

Drug resource mapping Dexlansoprazole Lansoprazole Omeprazole Pantoprazole

Clinical decision support:b Implementation workflow CYP2C19 consult Dexlansoprazole pre- and post-test alerts and flow charts Lansoprazole pre- and post-test alerts and flow charts Omeprazole pre- and post-test alerts and flow charts Pantoprazole pre- and post-test alerts and flow charts

^aSome of the tables included in the guideline may have been updated on-line, particularly to reflect newly described or newly characterized alleles. These include the gene-specific information tables (https://www.pharmgkb.org/page/pgxGeneRef) that support CPIC guidelines by providing information regarding star (*) allele definitions, allele function, allele frequency by major ethnic groups, translations of diplotype to phenotype, and gene resource mappings.

^bThese resources support the adoption of CPIC guidelines into the electronic health record with clinical decision support and provide information that clinical implementers find helpful.