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CPIC® Guideline for Proton Pump Inhibitors and CYP2C19

Most recent guideline publication:

Clinical Pharmacogenetics Implementation Consortium (CPIC) Guideline for CYP2C19 and Proton Pump Inhibitor Dosing (August 2020)

Updates since publication:

No updates on dosing recommendations since publication.

Tables provided in the main manuscript of the guideline:

Table 1. Assignment of predicted CYP2C19 phenotype based on genotype
Table 2. Dosing recommendations for omeprazole, lansoprazole, pantoprazole, and dexlansoprazole based on CYP2C19 phenotype

Supplement to: Clinical Pharmacogenetics Implementation Consortium (CPIC) Guideline for CYP2C19 and Proton Pump Inhibitor Dosing (August 2020)   

Tables provided in the guideline publication supplement or referenced in the guidelinea:

Table S1. Evidence linking CYP2C19 to omeprazole phenotype
Table S2. Evidence linking CYP2C19 to lansoprazole phenotype
Table S3. Evidence linking CYP2C19 to pantoprazole phenotype
Table S4. Evidence linking CYP2C19 to dexlansoprazole phenotype
Table S5. Evidence linking CYP2C19 to esomeprazole phenotype
Table S6. Evidence linking CYP2C19 to rabeprazole phenotype
Table S7. Evidence linking CYP2C19 to proton pump inhibitor phenotype (mixed cohort)
Table S8. Dosing recommendations for esomeprazole and rabeprazole based on CYP2C19 phenotype
CYP2C19 allele definition table
CYP2C19 allele functionality table
CYP2C19 frequency table
CYP2C19 diplotype-phenotype table

Gene resource mapping

CYP2C19 gene resource mappings

Drug resource mapping

Dexlansoprazole

Lansoprazole

Omeprazole

Pantoprazole

Clinical decision support:b

Dexlansoprazole pre- and post-test alerts and flow charts

Lansoprazole pre- and post-test alerts and flow charts

Omeprazole pre- and post-test alerts and flow charts

Pantoprazole pre- and post-test alerts and flow charts

aSome of the tables included in the guideline may have been updated on-line, particularly to reflect newly described or newly characterized alleles. These include the gene-specific information tables (https://www.pharmgkb.org/page/pgxGeneRef) that support CPIC guidelines by providing information regarding star (*) allele definitions, allele function, allele frequency by major ethnic groups, translations of diplotype to phenotype, and gene resource mappings.

bThese resources support the adoption of CPIC guidelines into the electronic health record with clinical decision support and provide information that clinical implementers find helpful.