Most recent guideline publication:
Clinical Pharmacogenetics Implementation Consortium (CPIC) Guidelines for Human Leukocyte Antigen-B (HLA-B) Genotype and Allopurinol Dosing (February 2013)
Updates since publication:
June 2015 update: Guideline authors reviewed additional literature and concluded that none of the evidence would change the therapeutic recommendations in the 2013 guideline; therefore, the 2013 guideline remains clinically current. The guideline supplement and evidence table were updated (see below).
Tables and figure provided in the main manuscript of the guideline:
| Figure 1. Working model for specific human leukocyte antigen (HLA)-B molecule interacting with a drug compound |
| Table 1. Association of HLA-B*58:01 with allopurinol-induced SCAR in different populations |
| Table 2. Recommended therapeutic use of allopurinol by HLA-B genotype |
Supplement to: Clinical Pharmacogenetics Implementation Consortium (CPIC) Guidelines for Human Leukocyte Antigen-B (HLA-B) Genotype and Allopurinol Dosing: 2015 Update (June 2015)
Tables and figures included in the supplement:
| Supplemental Table S1. Frequencies of alleles in major racial/ethnic groups |
| Supplemental Table S2. Detailed table of HLA-B*58:01 alleles in defined ethnic groups |
| Supplemental Table S3. Evidence Linking Genotype with Phenotype |
| Supplemental Table S4. Drug(s) that pertain to this guideline |
| Supplemental Table S5. Gene(s) that pertain to this guideline |
| Supplemental Figure S1. HLA-B*58:01 pharmacogenetic test result: clinical implementation workflow for EHR |
| Supplemental Figure S2. HLA-B*58:01 genotype and allopurinol: point of care clinical decision support |
| Supplemental Table S6. Example implementation of this guideline: pharmacogenetic genotype/phenotype summary entries |
| Supplemental Table S7. Example implementation of this guideline: point of care clinical decision support |
Original publication (February 2013):
- Clinical Pharmacogenetics Implementation Consortium (CPIC) Guidelines for Human Leukocyte Antigen-B Genotype and Allopurinol Dosing
- 2013 supplement
This guideline has been endorsed by the American Society of Health-System Pharmacists (ASHP).