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CPIC® Guideline for Clopidogrel and CYP2C19

Most recent guideline publication:

Clinical Pharmacogenetics Implementation Consortium Guideline for CYP2C19 Genotype and Clopidogrel Therapy: 2022 update (January 2022)

Updates since publication:

None

Tables in the main manuscript of the guideline:

Table 1. Assignment of Predicted CYP2C19 Phenotype Based on Genotype
Table 2. Antiplatelet therapy recommendations based on CYP2C19 phenotype when considering clopidogrel for cardiovascular indications
Table 3. Antiplatelet therapy recommendations based on CYP2C19 phenotype when considering clopidogrel for neurovascular indications

Supplement to: Clinical Pharmacogenetics Implementation Consortium Guidelines for CYP2C19 Genotype and Clopidogrel Therapy: 2022 update (January 2022)

Tables and figures included in the supplementa or referenced in the guideline:

Table S1. Evidence linking CYP2C19 to clopidogrel phenotype-Pharmacokinetics and pharmacodynamics
Table S2. Evidence linking CYP2C19 to clopidogrel phenotype-Cardiovascular indications
Table S3. Evidence linking CYP2C19 to clopidogrel phenotype-Neurovascular indications
Table S4. Evidence linking CYP2C19 to clopidogrel phenotype-Meta-analyses since 2013
Table S5. Comparison of guideline and label recommendations for CYP2C19-clopidogrel
Figure S1. Hepatic metabolism of clopidogrel
CYP2C19 allele definition table
CYP2C19 allele functionality table
CYP2C19 frequency table
CYP2C19 diplotype-phenotype table
Gene resource mapping

CYP2C19 gene resource mapping

Drug resource mapping

Clopidogrel

Clinical decision supportb:

CYP2C19 consult and implementation workflow

Clopidogrel pre- and post-test alerts and flow charts

aSome of the tables included in the guideline may have been updated on-line, particularly to reflect newly described or newly characterized alleles. These include the gene-specific information tables (https://www.pharmgkb.org/page/pgxGeneRef) that support CPIC guidelines by providing information regarding star (*) allele definitions, allele function, allele frequency by major ethnic groups, translations of diplotype to phenotype, and gene resource mappings.

bThese resources support the adoption of CPIC guidelines into the electronic health record with clinical decision support and provide information that clinical implementers find helpful.

2013 guideline:

Original publication (August 2011):

This guideline has been endorsed by the American Society of Health-System Pharmacists (ASHP).