Most recent guideline publication:
Clinical Pharmacogenetics Implementation Consortium (CPIC) Guideline for Dihydropyrimidine Dehydrogenase Genotype and Fluoropyrimidine Dosing: 2017 Update (October 2017)
Updates since publication:
No updates on dosing recommendations since 2017 publication.
Tables provided in the main manuscript of the guideline:
|Table 1. Assignment of likely DPD phenotype based on DPYD genotype|
|Table 2. Recommended dosing of fluoropyrimidines by DPD phenotype|
Supplement to: Clinical Pharmacogenetics Implementation Consortium (CPIC) Guideline for Dihydropyrimidine Dehydrogenase Genotype and Fluoropyrimidine Dosing: 2017 Update (October 2017)
Tables included in the supplement or referenced in the guidelinea:
|Supplemental Table S1. Evidence linking DPYD genotype with DPD phenotype and dihydropyrimidine toxicity|
|DPYD allele functionality table|
|DPYD frequency table|
|DPYD genotype-phenotype table|
Gene resource mapping
Drug resource mapping
Clinical decision supportb:
aSome of the tables included in the guideline may have been updated online, particularly to reflect newly described or newly characterized alleles. These include the gene-specific information tables (https://www.pharmgkb.org/page/pgxGeneRef) that support CPIC guidelines by providing information regarding star (*) allele definitions, allele function, allele frequency by major ethnic groups, translations of diplotype to phenotype, and gene resource mappings.
bThese resources support the adoption of CPIC guidelines into the electronic health record with clinical decision support and provide information that clinical implementers find helpful.
Original guideline publication (December 2013):
- Clinical Pharmacogenetics Implementation Consortium (CPIC) Guidelines for Dihydropyrimidine Dehydrogenase Genotype and Fluoropyrimidine Dosing (December 2013)
- 2013 supplement
- May 2014: The CPIC authors recommend that the DPYD*4, *5, *6 and *9A alleles be categorized as “normal” activity, in part based upon the recent publication Comparative Functional Analysis of DPYD Variants of Potential Clinical Relevance to Dihydropyrimidine Dehydrogenase Activity. (Please note this update was incorporated into the 2017 update).