CYP2D6 Genotype to Phenotype Standardization Project

Since pharmacogenetic clinical recommendations are based on phenotype, the assignment of phenotype based on genotype is an important aspect to clinical implementation and reporting of different inferred phenotypes across laboratories and guidelines has created considerable confusion and inconsistencies in recommendations. To maximize the utility of pharmacogenetic test results, it is desirable to standardize the phenotype prediction from genotype data. The purpose of this project was to determine consensus among CYP2D6 experts as to the definitions used to assign CYP2D6 phenotype based on genotype.

Project details and survey results: