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2012 Conference Call Minutes

minutes cpic april 5 2012 minutes cpic Dec 6 2012 minutes cpic Feb 2 2012 minutes cpic June 8 2012 minutes cpic mar 1 2012 minutes cpic May 3 2012 minutes cpic Nov 1 2012 minutes cpic Oct 4 2012 minutes cpic Sept 13 2012 WGS_CPIC guideline 12062012 meeting_Huser

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Term Standardization for Clinical Pharmacogenetic Test Results-Part 2

In 2016, CPIC led a consensus effort to standardize terms for clinical pharmacogenetic tests. The goal of the project was to create standardized terms for pharmacogenetic allele function and phenotypes to be used in CPIC guidelines (specifically Tables 1 and 2) and in the larger pharmacogenetics community (Term Standardization Part 1). However, additional standardization opportunities […]

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CPIC® Guideline for NSAIDs based on CYP2C9 genotype

Most recent guideline publication: Clinical Pharmacogenetics Implementation Consortium (CPIC) Guideline for CYP2C9 and NSAID Therapy (March 2020) Updates since publication: No updates on dosing recommendations since publication. Tables provided in the main manuscript of the guideline: Table 1. Assignment of likely CYP2C9 phenotypes based on genotypes Table 2. Therapeutic recommendations for celecoxib, flurbiprofen, lornoxicam and […]

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2019 CPIC Conference Call Minutes

February 2019 CYP2C19-Proton Pump Inhibitors Oslin slides March 2019 CPIC Twitter 101 Monte slides April 2019 Giacomini slides May 2019 Hoshitsuki slides Bousman/Mueller slides August 2019 FDA/PGx slides September 2019 Allele function assignment SOP and CYP2C9 function assignment CYP2C9 Genotyping Recommendations: AMP Pharmacogenomics Working Group AMP Clinical Practice Committee October 2019 CPIC update slides Relling […]

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CYP2D6 Genotype to Phenotype Standardization Project

Since pharmacogenetic clinical recommendations are based on phenotype, the assignment of phenotype based on genotype is an important aspect to clinical implementation and reporting of different inferred phenotypes across laboratories and guidelines has created considerable confusion and inconsistencies in recommendations. To maximize the utility of pharmacogenetic test results, it is desirable to standardize the phenotype […]

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CPIC® Guideline for Atomoxetine based on CYP2D6 genotype

Most recent guideline publication: Clinical Pharmacogenetics Implementation Consortium (CPIC) Guideline for CYP2D6 Genotype and Atomoxetine (February 2019) Updates since publication: October 2019: CYP2D6 genotype to phenotype translation changes: Up until August 2019, there were a few inconsistencies in the translation of CYP2D6 genotype to phenotype across guidelines (i.e. CPIC and DPWG) and between clinical genetic […]

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2018 CPIC Conference Call Minutes

February 2018 Thomas slides March 2018 Peterson slides Gregornik slides April 2018 Pulk slides Pratt slides May 2018 Caudle slides June 2018 Newman slides August 2018 2018 ASCO Endorsement Methods September 2018 CYP2D6 genotype to phenotype standardization project slides October 2018 November 2018 Huddart slides December 2018 Database/API slides

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CPIC® Guideline for Tamoxifen based on CYP2D6 genotype

Most recent guideline publication: Clinical Pharmacogenetics Implementation Consortium (CPIC) Guideline for CYP2D6 and Tamoxifen Therapy (January 2018)  Updates since publication: October 2019: CYP2D6 genotype to phenotype translation changes: Up until August 2019, there were a few inconsistencies in the translation of CYP2D6 genotype to phenotype across guidelines (i.e. CPIC and DPWG) and between clinical genetic testing […]

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Prioritization of CPIC Guidelines

Prioritizing the order of writing guidelines for CPIC genes/drugs is based on the following criteria: Is there prescribing actionability? What is the severity of the clinical consequences (adverse effects, lack of response) if genetics are not used to inform prescribing? Is the gene already subject to other CPIC guidelines? Is there an available genetic test […]

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CPIC® Guideline for Ondansetron and Tropisetron based on CYP2D6 genotype

Most recent guideline publication: Clinical Pharmacogenetics Implementation Consortium (CPIC) Guideline for CYP2D6 Genotype and Use of Ondansetron and Tropisetron (December 2016) Updates since publication: October 2019: CYP2D6 genotype to phenotype translation changes: Up until August 2019, there were a few inconsistencies in the translation of CYP2D6 genotype to phenotype across guidelines (i.e. CPIC and DPWG) […]

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