Search results for: “dpyd”

CPIC guideline for fluoropyrimidines based on DPYD genotype   For gene-specific information tables (i.e. DPYD allele definition, allele functionality, and frequency tables) see guideline pages or PharmGKB.

Most recent guideline publication: Clinical Pharmacogenetics Implementation Consortium (CPIC) Guideline for Dihydropyrimidine Dehydrogenase Genotype and Fluoropyrimidine Dosing: 2017 Update (October 2017) Updates since publication: January 2024 update (edited March 2024): Recently, individual patients have been reported (PMID 38129972) to carry only one of the two SNPs in the HapB3 haplotype (i.e., c.1236G>A without c.1129-5923C>G), suggesting…

February – Patel slides March–Stenehjem slides–Stevens slides April–Haidar slides

January Voora slides February Hertz slides Surprenant slides March CPIC update April May El Rouby slides June Saulsberry slides August Pratt slides Newman slides September October Tuteja slides December Caudle slides Phillips slides FDA response to codeine citizen petition

Prioritizing the order of writing guidelines for CPIC genes/drugs is based on the following criteria: CPIC guidelines published, in progress, or planned Gene – Drug Current CPIC level* Status TPMT, NUDT15 – thiopurines A Published; update in progress CYP2C19 – clopidogrel A Published CYP2C9,VKORC1, CYP4F2 – warfarin A Published CYP2D6 – opioids A Published HLA-B…