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CPIC® Guideline for Atomoxetine based on CYP2D6 genotype

Most recent guideline publication:

Clinical Pharmacogenetics Implementation Consortium (CPIC) Guideline for CYP2D6 Genotype and Atomoxetine (February 2019)

Updates since publication:

No updates on dosing recommendations since publication.

Tables and figure provided in the main manuscript of the guideline:

Table 1. Assignment of likely CYP2D6 phenotypes based on diplotypes
Table 2. Dosing recommendations for atomoxetine based on CYP2D6 genotype for children
Table 3. Dosing recommendations for atomoxetine based on CYP2D6 genotype for adults
Figure 1. Atomoxetine Pathway, Pharmacokinetics

Supplement to: Clinical Pharmacogenetics Implementation Consortium (CPIC) Guideline for CYP2D6 Genotype and Atomoxetine (February 2019)

Tables and figures provided in the supplement or referenced in the guidelinea:

Supplemental Table S1. Evidence linking CYP2D6 to atomoxetine phenotype
CYP2D6 allele definition table
CYP2D6 allele functionality table
CYP2D6 frequency table
CYP2D6 diplotype-phenotype table

Gene Resource Mapping

CYP2D6 gene resource mappings

Drug Resource Mapping

Atomoxetine

Clinical Decision Support:b

Atomoxetine pre- and post-test alerts and flow chart

aSome of the tables included in the guideline may have been updated online, particularly to reflect newly described or newly characterized alleles. These include the gene-specific information tables (https://www.pharmgkb.org/page/pgxGeneRef) that support CPIC guidelines by providing information regarding star (*) allele definitions, allele function, allele frequency by major ethnic groups, translations of diplotype to phenotype, and gene resource mappings.

bThese resources support the adoption of CPIC guidelines into the electronic health record with clinical decision support and provide information that clinical implementers find helpful.

This guideline has been endorsed by the American Society for Clinical Pharmacology and Therapeutics.