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Working group documents/information (posted as needed): Link to sign-up to be a clinical champion: https://forms.gle/SRQBQjApyCDrxKEv8 Working group minutes:  2021 January 2020 May June September November  

Clinical Pharmacogenetics Implementation Consortium (CPIC) has released the first version of its database and API to the public.  The CPIC Database is a relational database containing data from CPIC’s guidelines in structured formats.  This data includes the guideline manuscript recommendations and information from all of the supporting guideline tables, including gene variant and allele frequencies, function assignments,…

CPIC guideline for multiple drugs based on G6PD genotype   For gene-specific information tables (i.e. G6PD allele functionality and frequency tables) see guideline pages or PharmGKB.

CPIC guideline for fluoropyrimidines based on DPYD genotype   For gene-specific information tables (i.e. DPYD allele definition, allele functionality, and frequency tables) see guideline pages or PharmGKB.

Most recent guideline publication: Clinical Pharmacogenetics Implementation Consortium (CPIC) Guideline for CYP2C19 and Proton Pump Inhibitor Dosing (August 2020) Updates since publication: No updates on dosing recommendations since publication. Tables provided in the main manuscript of the guideline: Table 1. Assignment of predicted CYP2C19 phenotype based on genotype Table 2. Dosing recommendations for omeprazole, lansoprazole,…

In 2016, CPIC led a consensus effort to standardize terms for clinical pharmacogenetic tests. The goal of the project was to create standardized terms for pharmacogenetic allele function and phenotypes to be used in CPIC guidelines (specifically Tables 1 and 2) and in the larger pharmacogenetics community (Term Standardization Part 1). However, additional standardization opportunities…

CPIC has been assigning “function” to pharmacogenetic alleles since its inception, and this led to a Delphi process and consensus publication on standardizing terms used for allele function and pharmacogenetic phenotypes for some genes. The unique contribution of CPIC is to assign an allele function that leads to a phenotype assignment that can drive clinical…

Most recent guideline publication: Clinical Pharmacogenetics Implementation Consortium (CPIC) Guideline for CYP2C9 and NSAID Therapy (March 2020) Updates since publication: No updates on dosing recommendations since publication. Tables provided in the main manuscript of the guideline: Table 1. Assignment of likely CYP2C9 phenotypes based on genotypes Table 2. Therapeutic recommendations for celecoxib, flurbiprofen, lornoxicam and…

Goal and Focus A formal working group within CPIC, PharmGKB, PharmVar, and the PGRN was formed in 2018 to focus on the dissemination of resources available for pharmacogenetic implementation such as CPIC guidelines, PharmGKB, PGRN and PharmVar resources, and implementation strategies of pharmacogenetics. The goal of the CPIC Dissemination Working Group is to support the…

Most recent guideline publication: Clinical Pharmacogenetics Implementation Consortium (CPIC) Guideline for CYP2B6 and Efavirenz-containing Antiretroviral Therapy (April 2019) Updates since publication: No updates on dosing recommendations since publication. Tables and figure provided in the main manuscript of the guideline: Table 1. Assignment of likely CYP2B6 phenotypes based on genotypes Table 2. Efavirenz dosing recommendations based…