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February 2018 Thomas slides March 2018 Peterson slides Gregornik slides April 2018 Pulk slides Pratt slides May 2018 Caudle slides June 2018 Newman slides August 2018 2018 ASCO Endorsement Methods September 2018 CYP2D6 genotype to phenotype standardization project slides October 2018 November 2018 Huddart slides December 2018 Database/API slides

Most recent guideline publication: Clinical Pharmacogenetics Implementation Consortium (CPIC) Guideline for CYP2D6 and Tamoxifen Therapy (January 2018) Updates since publication: October 2019: CYP2D6 genotype to phenotype translation changes: Up until August 2019, there were a few inconsistencies in the translation of CYP2D6 genotype to phenotype across guidelines (i.e. CPIC and DPWG) and between clinical genetic…

Prioritizing the order of writing guidelines for CPIC genes/drugs is based on the following criteria: CPIC guidelines published, in progress, or planned Gene – Drug Current CPIC level* Status TPMT, NUDT15 – thiopurines A Published; update in progress CYP2C19 – clopidogrel A Published CYP2C9,VKORC1, CYP4F2 – warfarin A Published CYP2D6 – opioids A Published HLA-B…

Most recent guideline publication: Clinical Pharmacogenetics Implementation Consortium (CPIC) Guideline for CYP2D6 Genotype and Use of Ondansetron and Tropisetron (December 2016) Updates since publication: October 2019: CYP2D6 genotype to phenotype translation changes: Up until August 2019, there were a few inconsistencies in the translation of CYP2D6 genotype to phenotype across guidelines (i.e. CPIC and DPWG)…

Most recent guideline publication: Clinical Pharmacogenetics Implementation Consortium (CPIC) Guideline for CYP2C19 and Voriconazole Therapy (December 2016) Updates since publication: No updates on dosing recommendations since publication. Tables provided in the main manuscript of the guideline: Table 1. Assignment of likely CYP2C19 phenotype based on genotypes Table 2. Dosing recommendations for voriconazole based on CYP2C19…

CPIC guidelines and projects have been endorsed by several professional societies. The Association for Molecular Pathology (AMP) has endorsed CPIC’s Term Standardization for Clinical Pharmacogenetics Test Results Project. The American Society for Clinical Pharmacology and Therapeutics (ASCPT) Board of Directors has endorsed CPIC guidelines. The American Society of Health-System Pharmacists (ASHP) has endorsed multiple CPIC guidelines.

ClinPGx 2024 Meeting Registration open In collaboration with CPIC, PharmGKB, PharmCAT and PharmVar, the Penn Institute for Biomedical Informatics will be hosting the ClinPGx 2024: Knowledge, Implementation, Education meeting on June 20th and 21st, 2024 in Philadelphia, PA. This meeting will provide educational content to cover all aspects of PGx implementation. Participants are invited to submit…

Most recent guideline publication: Clinical Pharmacogenetics Implementation Consortium (CPIC) Guidelines for CYP2C9 and HLA-B Genotype and Phenytoin Dosing (August 2020) Updates since publication: No updates on dosing recommendations since publication. Tables and figure provided in the main manuscript of the guideline: Table 1. Assignment of likely HLA-B phenotypes based on genotypes Table 2. Assignment of…

Most recent guideline publication: Clinical Pharmacogenetics Implementation Consortium Guideline for CYP2C19 Genotype and Clopidogrel Therapy: 2022 update (January 2022) Updates since publication: None Tables in the main manuscript of the guideline: Table 1. Assignment of Predicted CYP2C19 Phenotype Based on Genotype Table 2. Antiplatelet therapy recommendations based on CYP2C19 phenotype when considering clopidogrel for cardiovascular…

Most recent guideline publication: Clinical Pharmacogenetics Implementation Consortium (CPIC) Guidelines for Pharmacogenetics-guided Warfarin Dosing: 2016 Update (December 2016) Updates since publication: No updates on dosing recommendations since this publication. Figures provided in the main manuscript of the guideline: Figure 1. Schematic representation of warfarin metabolism and its mechanism of action. Figure 2. Dosing recommendations for…