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Most recent guideline publication: Clinical Pharmacogenetics Implementation Consortium (CPIC) Guideline for CYP2C19 and Proton Pump Inhibitor Dosing (August 2020) Updates since publication: No updates on dosing recommendations since publication. Tables provided in the main manuscript of the guideline: Table 1. Assignment of predicted CYP2C19 phenotype based on genotype Table 2. Dosing recommendations for omeprazole, lansoprazole,…

In 2016, CPIC led a consensus effort to standardize terms for clinical pharmacogenetic tests. The goal of the project was to create standardized terms for pharmacogenetic allele function and phenotypes to be used in CPIC guidelines (specifically Tables 1 and 2) and in the larger pharmacogenetics community (Term Standardization Part 1). However, additional standardization opportunities…

CPIC has been assigning “function” to pharmacogenetic alleles since its inception, and this led to a Delphi process and consensus publication on standardizing terms used for allele function and pharmacogenetic phenotypes for some genes. The unique contribution of CPIC is to assign an allele function that leads to a phenotype assignment that can drive clinical…

Most recent guideline publication: Clinical Pharmacogenetics Implementation Consortium (CPIC) Guideline for CYP2C9 and NSAID Therapy (March 2020) Updates since publication: No updates on dosing recommendations since publication. Tables provided in the main manuscript of the guideline: Table 1. Assignment of likely CYP2C9 phenotypes based on genotypes Table 2. Therapeutic recommendations for celecoxib, flurbiprofen, lornoxicam and…

Goal and Focus A formal working group within CPIC, PharmGKB, PharmVar, and the PGRN was formed in 2018 to focus on the dissemination of resources available for pharmacogenetic implementation such as CPIC guidelines, PharmGKB, PGRN and PharmVar resources, and implementation strategies of pharmacogenetics. The goal of the CPIC Dissemination Working Group is to support the…

February 2019 CYP2C19-Proton Pump Inhibitors Oslin slides March 2019 CPIC Twitter 101 Monte slides April 2019 Giacomini slides May 2019 Hoshitsuki slides Bousman/Mueller slides August 2019 FDA/PGx slides September 2019 Allele function assignment SOP and CYP2C9 function assignment CYP2C9 Genotyping Recommendations: AMP Pharmacogenomics Working Group AMP Clinical Practice Committee October 2019 CPIC update slides Relling…

Since pharmacogenetic clinical recommendations are based on phenotype, the assignment of phenotype based on genotype is an important aspect to clinical implementation and reporting of different inferred phenotypes across laboratories and guidelines has created considerable confusion and inconsistencies in recommendations. To maximize the utility of pharmacogenetic test results, it is desirable to standardize the phenotype…

Most recent guideline publication: Clinical Pharmacogenetics Implementation Consortium (CPIC) Guideline for CYP2D6 Genotype and Atomoxetine (February 2019) Updates since publication: October 2019: CYP2D6 genotype to phenotype translation changes: Up until August 2019, there were a few inconsistencies in the translation of CYP2D6 genotype to phenotype across guidelines (i.e. CPIC and DPWG) and between clinical genetic…

Most recent guideline publication: Clinical Pharmacogenetics Implementation Consortium (CPIC) guideline for the use of potent volatile anesthetic agents and succinylcholine in the context of RYR1 or CACNA1S genotypes Updates since publication: December 2023: Subsequent to the publication of the CPIC guideline for RYR1 and malignant hyperthermia (PMID 30499100), the ClinGen variant curation expert panel (VCEP) developed and published…

February 2018 Thomas slides March 2018 Peterson slides Gregornik slides April 2018 Pulk slides Pratt slides May 2018 Caudle slides June 2018 Newman slides August 2018 2018 ASCO Endorsement Methods September 2018 CYP2D6 genotype to phenotype standardization project slides October 2018 November 2018 Huddart slides December 2018 Database/API slides